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Table 4 Contribution of body composition and abdominal fat distribution to glomerular filtration rate after stratification by sex and metabolic syndrome

From: Relationship between bmi and glomerular filtration rate in a large cohort initiating a weight loss program: differential contributions of fat mass, fat-free mass, and abdominal fat compartments

 

Women

No metabolic syndrome

Metabolic syndrome

M1

M2

M3

M4

M5

M1

M2

M3

M4

M5

BMI (kg/m2)

−0.18***

0.94***

   

0.20***

0.53***

   
 

[−0.27,−0.09]

[0.82,1.06]

   

[0.01,0.39]

[0.31,0.75]

   

Body fat (%)

 

−1.41***

    

−1.08***

   
  

[−1.52,−1.29]

    

[−1.48,−0.69]

   

FMI (kg/m2)

  

−2.88***

−3.45***

−3.14***

  

−1.59***

−1.46***

−1.18**

   

[−3.10,−2.67]

[−3.74,−3.17]

[−3.42,−2.86]

  

[−2.20,−0.98]

[−2.12,−0.80]

[−1.84,−0.52]

FFMI (kg/m2)

  

3.72***

3.46***

3.21***

  

2.18***

1.80***

1.59***

   

[3.43,4.01]

[3.17,3.75]

[2.93,3.50]

  

[1.53,2.83]

[1.18,2.41]

[0.99,2.19]

VAT (cm)

   

−0.68***

−0.62***

   

−0.89***

−0.85***

    

[−0.98,−0.38]

[−0.91,−0.32]

   

[−1.35,−0.42]

[−1.32,−0.37]

SAT (cm)

   

3.71***

3.43***

   

4.25***

4.08***

    

[3.21,4.20]

[2.95,3.90]

   

[3.26,5.24]

[3.09,5.07]

Impaired fasting glucose (yes)

    

−3.39***

    

−1.67

     

[−4.65,−2.12]

    

[−3.87,0.54]

High triglycerides (yes)

    

0.29

    

−2.09*

     

[−2.09,1.51]

    

[−4.05,−0.13]

High blood pressure (yes)

    

−5.92***

    

−7.82***

     

[−6.90,−4.93]

    

[−10.34,−5.32]

Low HDL cholesterol (yes)

    

2.30**

    

0.12

     

[0.87,3.73]

    

[1–88,2.13]

Structured physical activity (≥ 2 h/w)

    

−3.03***

    

−0.95

     

[−3.83, −2.23]

    

[−2.63,0.73]

Constant

106.17***

128.18***

68.18***

71.49***

76.17***

86.46***

121.17***

73.97***

71.54***

80.15***

 

[103,64,108.71]

[124.96,131.39]

[64.72,71.63]

[68.02,74.95]

[72.71,79.62]

[80.25,92.67]

[106.75,135.59]

[67.02,80.91]

[64.91,78.17]

[72.49,87.80]

Observations

5539

5539

5539

5539

5539

1473

1473

1473

1473

1473

VIF

-

2.04

2.30

2.45

1.78

-

1.36

2.80

2.34

1.77

AIC

46,842

46,267

46,135

45,864

45,634

12,636

12,596

12,584

12,451

12,405

 

Men

No metabolic syndrome

Metabolic syndrome

M1

M2

M3

M4

M5

M1

M2

M3

M4

M5

BMI (kg/m2)

−0.23*

1.12***

   

0.47***

1.22***

   
 

[−0.44,−0.02]

[0.84,1.40]

   

[0.26,0.68]

[0.99,1.45]

   

Body fat (%)

 

−1.35***

    

−1.35***

   
  

[−1.53,−1.18]

    

[−1.58,−1.12]

   

FMI (kg/m2)

  

−2.29***

−2.82***

−2.62***

  

−1.42***

−1.66***

−1.51***

   

[−2.63,−1.94]

[−3.28,−2.36]

[−3.07,−2.15]

  

[−1.81,−1.04]

[−2.09,−1.24]

[−1.93,−1.08]

FFMI (kg/m2)

  

2.45***

1.90***

1.83***

  

2.65***

2.01***

1.94***

   

[2.02,2.88]

[1.45,2.35]

[1.38,2.29]

  

[2.24,3.06]

[1.56,2.46]

[1.50,2.40]

VAT (cm)

   

−0.35

−0.39

   

−0.09

−0.07

    

[−0.78, 0.08]

[−0.82,−0.04]

   

[−0.53,0.36]

[−0.51,0.38]

SAT (cm)

   

4.17***

3.96*

   

3.64***

3.47***

    

[3.30,5.05]

[3.09,4.84]

   

[2.80,4.48]

[2.63,4.34]

Impaired fasting glucose (yes)

    

−2.24*

    

−1.81

     

[−3.98,−0.49]

    

[−3.88,0.25]

High triglycerides (yes)

    

−2.54

    

0.38

     

[−4.92,−0.16]

    

[−1.57,2.33]

High blood pressure (yes)

    

−4.51***

    

−5.03**

     

[−6.08,−2.93]

    

[−7.93,−2.13]

Low HDL cholesterol (yes)

    

1.60

    

1.94*

     

[−1.16,4.35]

    

[0.05,3.84]

Structured physical activity (≥ 2 h/w)

    

−2.43**

    

−0.82

     

[−3.97,−0.88]

    

[−2.55,0.91]

Constant

106.17***

106.53***

69.44***

76.34***

80.81***

78.43***

99.81***

52.70***

59.37***

64.39***

 

[103,64,108.71]

[101.02,112.04]

[61.73,77.16]

[68.62,84.07]

[72.93,88.72]

[71.43,85.43]

[92.09,107.53]

[45.04,60.37]

[51.55,67.19]

[55.47,73.30]

Observations

1539

1539

1539

1539

1539

1153

1153

1153

1153

1153

VIF

-

1.89

1.33

1.86

1.45

-

1.36

1.28

1.51

1.86

AIC

12,947

12,729

12,755

12,652

12,612

9734

9612

9610

9530

9514

  1. Values are regression coefficients and 95% confidence intervals obtained from multivariable linear regression models
  2. M1: univariate: BMI (continuous)
  3. M2: multivariate: M1 + total body fat (continuous)
  4. M3: multivariate: FMI (continuous), FFMI (continuous)
  5. M4: multivariate: M3 + VAT (continuous), SAT (continuous)
  6. M5: multivariate: M4 + impaired fasting glucose (discrete), high blood pressure (discrete), high triglycerides (discrete), low HDL-cholesterol (discrete) and physical activity (discrete)
  7. Abbreviations: FMI fat mass index, FFMI fat-free mass index, VAT visceral adipose tissue, SAT subcutaneous adipose tissue, VIF Variance Inflation Factor, AIC Akaike Information Criterion
  8. *p < 0.05
  9. **p < 0.01
  10. ***p < 0.001